Our goals are to highlight recent developments in clinically relevant PEEK research and to stimulate hypothesis-driven investigations related to medical grade polyaryletherketones.
A new textbook dedicated to PEEK Biomaterials, edited by Dr. Steve Kurtz, has been published as part of the Plastics Design Library by Elsevier Inc. This Handbook brings together experts in many different facets related to PEEK clinical performance as well as in the areas of materials science, tribology, and biology to provide a complete reference for specialists in the field of plastics, biomaterials, medical device design and surgical applications. This book can be ordered at Amazon.
The Implant Research Center of Drexel University and Exponent, Inc., are pleased to announce a one month extension of the deadline for abstracts for the 3rd International PEEK Meeting, which will be convened at The Cosmos Club, Washington, DC, USA on April 27 and 28, 2017. The purpose of the conference is to bring together engineers, scientists, regulators, and clinicians from academia, industry, and government agencies for the presentation of leading edge research on advancements in medical grade polyaryletherketone (PAEK) polymer technology and clinical applications. Although all scientific studies, clinical applications and innovations related to the broad family of medical grade PAEKs are welcome at this conference, the majority of submissions are anticipated to be related to implantable PEEK and its composites. Click here for more information on the abstract template and the extended submission deadline for the PEEK Meeting.
Little is known about the biotribology of all-polymer PEEK bearings. Researchers from Philadelphia simultaneously tested a total of 100 pin-on-disk couples (n = 10 per bearing couple) consisting of three traditional metal-on-UHMWPE and seven polymer-on-polymer bearings for 2 million cycles under physiologically relevant conditions per ASTM F732. The combined wear rates of all-polymer bearing couples were not different than traditional bearing couples. The data suggest that all-polymer bearings, especially PEEK-on-HXLPE bearing couples, may represent a viable alternative to traditional bearings with respect to their wear performance.
Researchers from the University of Leeds performed a systematic review of the literature related to the biological response of PEEK wear particles. They found that wear particles produced by PEEK-based bearings were, in almost all cases, in the phagocytozable size range (0.1-10 microm). The studies that evaluated the biologic response to PEEK-based particles generally found cytotoxicity to be within acceptable limits relative to the UHMWPE control, but inconsistent when inflammatory cytokine release was considered.
Researchers from Prince of Wales Hospital in Australia investigated bone ongrowth and fusion outcomes of PEEK/HA as compared with natural PEEK in a cervical fusion model. Incorporating HA into the PEEK matrix resulted in more direct bone apposition as opposed to the fibrous tissue interface with PEEK alone in the bone ongrowth as well as interbody cervical fusions. No adverse reactions were found at the implant-bone interface for either material.
At the May 2016 ASTM meeting in San Antonio, TX, the task force announced the publication of the updated trace levels of heavy metals in medical grade PEEK in ASTM F2026 -16 (Standard Specification for Polyetheretherketone (PEEK) Polymers for Surgical Implant Applications). The task force discussed and approved a new work item to characterize consolidation defects and extranous matter, which will be discussed at future meetings. The next task force meeting will convene with the rest of F04 on Wed, November 16, 2016, in Orlando, FL.
The 3rd International PEEK meeting will be reconvened in Washington, D.C., in April 27-28 2017. The purpose of the meeting is to bring together engineers, scientists, regulators, and clinicians from academia, industry, and government agencies and present leading edge research on advancements in medical grade PEEK technology and clinical applications. The first day of the conference will include focused sessions on regulatory aspects of PEEK medical devices, organized in collaboration with scientists from FDA.
Principal Organizers: The meeting will be organized by Steve Kurtz (Chair) in collaboration with Joanne Tipper (University of Leeds), Oana Ghita (Exeter University), as well as John Bowsher and Kate Kavlock (FDA CDRH).
Venue: The meeting will be convened at the Cosmos Club, located in the Embassy Row district of downtown Washington D.C.. The Cosmos Club is in walking distance of a wide range of accomodations and the downtown attractions.
Registration: Check back soon for more details on how to register for the meeting and associated registration costs.
Accommodations: Based on feedback from last year's meeting we have elected not to reserve a meeting block, because of the plethora of hotels near the conference venue. In particular, we recommend contacting the Fairfax at Embassy Row as the preferred hotel for the conference, as it is located adjacent to the conference venue.
Social Program: The organizers believe that collaborations flourish not only in the formal structure of a meeting but more often in informal social gatherings. To that end, we will be organized a gala dinner on evening of Thursday, April 27. The cost of the social program will be covered in the conference registration fee.