Featured Publications & Reports

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In Vitro Response of Human Osteoblasts to PEEK Substrates Compared to CP Ti

In this study, different forms of implantable grade PEEK were compared with commercially pure titanium (cpTi) Grade 1 using a human primary osteoblast model. A varied response was observed at different time points during the study, suggesting that material formulation (unfilled PEEK or CFR-PEEK), subjection to industrial processing, surface roughness and topography may all influence the cellular response of osteoblasts to PEEK. Thus, differences in human osteoblast responses were found to the various samples of PEEK, but implantable grade PEEK, in general, was comparable in vitro to the bone forming capacity of rough titanium.

Analysis of a Retrieved CFR-PEEK Acetabular Liner

A wear couple consisting of carbon fiber-reinforced poly-ether-ether-ketone (CF-PEEK) has been shown to be highly biocompatible and to have excellent tribological performance in the laboratory. This case study reports the results of a technical and histologic analysis of a CF-PEEK composite acetabular cup component articulating against an alumina-head total hip arthroplasty prosthesis retrieved because of posttrauma infection from a patient in whom the components had been in place for 28 months.

Pre-Clinical Studies to Validate the MITCH PCR Cup

Researchers from London and Cambridge have developed a novel, horseshoe-shaped acetabular cup fabricated from CFR-PEEK articulating against an alumina femoral head. Simulated loading was performed using finite element analysis. Mechanical and tribological tests were performed to ensure the robustness of the new optimised design. Bio-compatibility of the articulation couple was demonstrated using an animal model. Implantation of the device has been extensively tested and re-validated in vitro to achieve a favourable polar contact between cup and femoral head and establish a reproducible operative technique. This preliminary work is undertaken prior to commencing a post market surveillance study of the CE marked implant.

Amorphous and crystalline polyetheretherketone: Mechanical properties and tissue reactions during a 3-year follow-up

The study was aimed to test the mechanical strength, structural stability, and tissue reactions of optically amorphous and crystalline polyetheretherketone (PEEK) plates during a 3-year follow-up in vivo and in vitro. The injection-moulded PEEK plates were implanted to the dorsal subcutis of 12 sheep, which were sacrificed at 6-156 weeks. Both optically amorphous and crystalline PEEK plates were fount to be suitable for the fixation of fractures and osteotomies.

Processing and tensile properties of hydroxyapatite-whisker-reinforced polyetheretherketone.

Researchers from the University of Notre Dame have reinforced PEEK with 0-50 vol% hydroxyapatite (HA) whiskers using a novel powder processing and compression molding technique which enabled uniform mixing at high whisker content. Texture analysis showed that viscous flow during compression molding produced a preferred orientation of whiskers along the specimen tensile axis. Consequently, the elastic modulus or ultimate tensile strength of HA-whisker-reinforced PEEK was able to be tailored to mimic human cortical bone.

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